Oh boy, Down the Rabbit hole we go Alice...

This should be a fun thread to read...
My thoughts in no particular order... I've tried my best to avoid some more esoteric choices...
Alco HH600Early alco switcher with a successful HO model.
Alco RS27Little oddball owned by enough railroads it might be successful, at least as many schemes as the SD24 or C420.
Alco RSD15Alligators, mostly for the cool factor. ATSF fans would eat them up.
Alco C424/C425The Lifelike Canada model is dead, they take premium prices on EBay. A later phase like the Atlas HO model would be nice.
Baldwin RS12Prolific little switcher, sells well in HO.
Baldwin AS616Consistently see lots of requests for this locomotive.
Baldwin DT66-2000Big transfer units, will sell due to cool factor.
EMD MP15ACMust have for MILW and SP fans.
EMD GP50Depending on how successful the FVM GP60 and Atlas GP39-2 are, a replacement for the old Kato model would be the missing link in 4 axle EMDs
EMD GP40LWCN 70's cool that's made its way to just about every corner of the States
EMD SD18Pair this with a retooled series of SD7/9's, the C&O version is especially cool with its ALCO trucks.
Fairbanks Morse H-10-44 / H-12-44Owned by more then 30 railroads, the HO model is pretty successful.
GE U33c / U36calways hear requests for these big GE's
GE U50Big UP power... 'nuff said

something equal to the quality of the Athearn HO model would be jaw dropping.
@scaletrains seems up your alley...
MLW M630 / M636Owned en mass by the big three Canadian Railroads, enough of these made it to the second hand market to give a few runs worth of paint schemes.
Rebuilt EMD Paducah GP10Prolific on the second hand market, these IC rebuilds scream cool.
Rebuilt EMD CF7Variations make this a tough choice but Athearn/RPP pulled it off in HO and nearly every layout set since the 1980's can justify one.
Rebuilt EMD GP20-ecoWith over 1500 built this is fast becoming the modern equivalent on CP of a GP9 or GP38 this one is a bit of a stretch being a 1 road unit.
As far as steam goes I have to agree with
@jpwisc that a Milw 4-8-4 would be a no brainer, Kato could package it with a friends of 261 excursion train...
Other possibilities
- USRA light Mikado
- USRA light Pacific
- Russian Decapod
- CP 4-6-4 (Either Royal Hudson or H1B empress)
- CN 4-8-4 (bullet nosed Betty)
- DMIR 2-8-8-4 Yellowstone