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First, f22 is way too small an aperture and you are going to get noticeable diffraction using it...Usually f8 is the sharpest aperture, and has the least amount of varying distortions, but I'd experiment with one stop above that, and one below just to make sure.
I set the aperture to f/8 which resulted in a 1/4 second exposure, and I was able to move the focus point through the scene progressively and precisely with the computer.