If the speaker or speaker/enclosure is loose in that cavity (I'm using cavity instead of enclosure here to avoid confusion), it could lead to unwanted noise from vibration. These speakers vibrate at a very fast rate and if part of it is (loosely) contacting the surrounding cavity, it could manifest as severe crackling or static-like sounds, especially if the cavity is made of rigid plastic or metal.
Also, if there's indeed a speaker loosely sitting in that cavity with no sealed enclosure attached to it, you could expect nothing but terrible noise. The cavity alone is not going to cut it, unless the speaker is sealed against the side with the perforations (so long as the perforations don't extend beyond the L x W dimensions of the speaker) and the rest of the cavity forms a sealed enclosure. One side of the speaker has to be completely isolated from the other side or bad things tend to happen.