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Your cars wheel set flange size will also play a part in this along with the layouts track geometry, an example. I have two, 2 scale mile long helix's with 21 inch radius curves and a 2.1% grade. My freight train size is 34 car freight cars + caboose (using low flange wheel sets). I found that at some point going down into one helix, the rear of the train would run in the slack onto the trains front. Unlike a real trains I could not set the brakes. As it turned out under the front of the train's leading cars was a turnout. All of a sudden the weight of my train was onto the 1st few cars as the slack ran in. It was much like backing up - except I was going forward. The truck mounted couplers how were being pushed from behind skewing the trucks causing derailments (at times). Body mounted couplers the fixed the problem.