Being a die-hard B&O fan, I will cast your vote for the latter. True mountain railroading here. Keyser had a large engine facility/roundhouse and the yard would provide good proto-operation. Eastbound drags required doubling the hill. At Keyser, both units of the drag were reassembled and went east usually through the patterson creek cutoff.
Going west from Keyser, you could interchange with Lee at Westvaco Paper in Luke. The climb started at the Bloomington Viaduct for 17 miles. If modeling pre-58, you could have Bond and Streckers operational with their 12% run-away safety spurs. At the summit, the wye at Altamont allows helpers to back down. The beautiful Oakland station. The vertical curve at Terra Alta going into the horseshoe curve at Salt Lick Curve would make a great railfanning location for photos. Three tracks here full of action with helpers backing down from Terra Alta to Rowlesburg. M&K Junction, the shrine to all B&O fans beckons to be modeled again and agin (spelled right for the area).
The Cheat River grade would be a great in N since it would allow the grade, large drop-offs and mountains to bring out the best in N. Some great points on this grade too; 76 Fill, the 100ft Buckeye Wall, Tray Run Viaduct, Buckhorn Wall and the summit at Tunnelton with the duel bores. By comparison, the downgrade to Grafton is a peaceful march. Grafton could be a layout unto itself.
Sorry for rambling all, but the West End has my heart and interest. So, When are you starting Steve??