Please understand that people are honestly trying to help. It's probably not the flanges.
Large flanges really only help make up for primarily deficiencies in weight (many old 1960s and 70 cars were under weight) and/or problematic track work.
On my layout, I try to pay attention to where derailments happen. If there is a pattern, I begin systematic checking.
- are wheels gauged properly?
- is there a problem with the track? (gauge? uneven? big gaps? a spot where curve is too tight?)
- sometimes the problem is a coupler which becomes a problem on curves
Do you have an NMRA track gauge? Very helpful if you don't.
https://handlaidtrack.com/product/tl-0017/?v=0b3b97fa6688Hope you find out what's going on.