Hi Tony.
If you download the LokSound 5 manual and look at pages 39-40 and 80-83, you'll see that there is some discussion of smoke unit control with the LokSound 5. On pages 82-83, there is a list of function key settings, which includes several references to smoke generator control, including sound controlled smoke unit, Seuthe smoke unit, fan control, steam trigger, etc.
Since I only do N scale, I don't know what any of these things do, or if you can adjust them for use with a BLI smoke unit. You might want to consider posting a question on the ESU LokSound group at Groups.io that Peteski linked to; folks there should be able to help, since there are a lot of HO and larger scale modelers on that group.
John C.